Table 1.

Spectrum of tumors occurring in Mdm2-transgenic mice

Mdm2-transgenic micea	Mdm2 transgenic/p53-null miceb	p53-null micec
14 Malignant lymphoma	14 Malignant lymphoma	35 Malignant lymphoma
9 Hemangiosarcoma	8 Hemangiosarcoma	2 Osteosarcoma
1 Rhabdomyosarcoma	2 Osteosarcoma	1 Rhabdomyosarcoma
1 Adenocarcinoma	1 Squamous cell carcinoma	1 Undifferentiated sarcoma
1 Pituitary adenoma	1 Medulloblastoma	3 Carcinomas
10/26 Tumors = sarcomas (38%)	10/26 Tumors = sarcomas (38%)	4/42 Tumors = sarcomas (9%)

Tumors isolated from 22 Mdm2-transgenic, p53 +/+ mice, 21 Mdm2-transgenic, p53 −/− mice were classified by histopathology. Numbers in parentheses represent the percentage of all tumors that are sarcomas.