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. 2010 Jan 21;5(1):e8840. doi: 10.1371/journal.pone.0008840

Figure 4. Treatment with shRNA-S100a9 attenuated learning and memory impairment in Tg2576 mice.

Figure 4

(A) Morris water maze task was performed 2 months after lentiviral infection. The task was conducted for 9 consecutive days. A significant difference was observed between the Tg_sh-S100a9 group and the Tg_sh-CTL group from the 6th day of the Morris water maze task. (B) The probe test was carried out 48 h after the final trial. Tg_sh-S100a9 group showed memory improvement compared to Tg_sh-CTL in zone 4 where the platform had been hidden (nā€Š=ā€Š8 per group). **P<0.01, ***P<0.001 by one-way ANOVA.