Table 2.
Key Characteristics of Cancer Patients by Presence or Absence of DLT (N=242)
| Characteristic | DLT Present (N=63) |
DLT Absent (N=173) |
p-value |
|---|---|---|---|
| % or Mean | % or Mean | ||
| Age (years), mean(SD) | 60.2 (13.4) | 56.2 (12.6) | 0.039 |
| Gender, %(N) | |||
| Male | 55.6 (35) | 56.7 (98) | 0.883 |
| Female | 44.4 (28) | 43.4 (75) | |
| Marital Status, %(N) | |||
| Single | 9.8 (6) | 19.3 (32) | 0.110 |
| Married | 90.2 (55) | 80.7 (134) | |
| Census Zip Code Median Houshold Income in $1000s, mean(SD) | 50.4 (11.7) | 46.4 (11.3) | 0.029 |
| Percent of Census Block Aged 25+ with a Bachelor’s Degree, mean(SD) | 15.5 (6.5) | 15.8 (7.1) | 0.748 |
| Distance to Hospital (miles), mean(SD) | 72.5 (47.9) | 91.2 (81.8) | 0.091 |
| Smoking Status, %(N) | |||
| Never a Smoker | 47.3 (26) | 40.5 (60) | |
| Former Smoker | 43.6 (24) | 42.6 (63) | 0.375 |
| Current Smoker | 9.1 (5) | 16.9 (25) | |
| Number of Pack Years, mean(SD) | 18.7 (27.8) | 18.3 (23.2) | 0.915 |
| Height (cm), mean(SD) | 170.5 (11.5) | 171.3 (10.8) | 0.621 |
| Weight (Kg), mean(SD) | 75.4 (15.4) | 81.9 (20.5) | 0.023 |
| Body Surface Area (m2), mean(SD) | 1.88 (0.23) | 1.96 (0.28) | 0.039 |
| Dose, %(N) | |||
| MTD | 31.8 (20) | 54.9 (95) | 0.002 |
| Above MTD | 68.3 (43) | 45.1 (78) | |
| Duration of Diagnosis in months, mean(SD) | 25.5 (26.7) | 32.3 (38.3) | 0.196 |
| Number of Prior Therapies, mean(SD) | 2.4 (1.9) | 2.5 (1.7) | 0.825 |
| Numer of Medications, mean(SD) | 4.5 (3.7) | 4.4 (3) | 0.927 |
| CIR-G Total Score, mean(SD) | 7.3 (2.5) | 7.5 (2.6) | 0.651 |
| ECOG-PS, %(N) | |||
| Restricted | 80.3 (49) | 71.3 (119) | 0.179 |
| Fully Active | 19.7 (12) | 28.7 (48) | |
| Lab Data, mean(SD) | |||
| ALK PHOS (U/L) | 184.6 (165.5) | 141.7 (113.2) | 0.029 |
| WBC (K/uL) | 7 (2.5) | 7.2 (4.1) | 0.692 |
| ANC (cells/uL) | 5030.1 (2349.3) | 4931.8 (2398.3) | 0.783 |
| HGB (K/uL) | 12.1 (1.5) | 12.6 (1.7) | 0.044 |
| PLT (K/uL) | 268.6 (113.6) | 267.8 (99.4) | 0.960 |
| CREAT (mg/dL) | 0.9 (0.2) | 0.9 (0.2) | 0.680 |
| ALB (g/dL) | 3.5 (0.5) | 3.7 (0.5) | 0.056 |
| LDH (U/L) | 537 (854.9) | 290.9 (234) | 0.002 |
Bold indicates P<.05