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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: J Neurochem. 2009 Oct 28;112(1):307–317. doi: 10.1111/j.1471-4159.2009.06460.x

Fig. 1. Concentration-response curves for ATP (0.1–100 μM)-activated currents in Xenopus oocytes expressing WT and mutant (D331A, M336A and D331A-M336A) receptors.

Fig. 1

ATP-activated currents were normalized to the maximal current activated by a saturating concentration of ATP (100 μM). The curves represent non-linear regression analysis of the ATP concentration-responses in the WT and mutant P2X4Rs. Details of maximal current amplitude (Imax), EC50 and Hill Slope and are provided in Table 2. The similarity in the ATP concentration-response curves for WT vs. mutant receptors suggesting that the mutants did not markedly alter normal receptor function. Each data point represents the mean ± SEM from at least five different oocytes. Note: the symbol legends for the bottom and top points of the concentration response curves are lying on top of each other and thus appear as a black box at each of these positions.