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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: J Neurochem. 2009 Nov 11;112(3):691–702. doi: 10.1111/j.1471-4159.2009.06489.x

Figure 5.

Figure 5

Exposure to Δ9-THC induces changes in the ratio of AMPA/NMDA receptor-gated currents. A1. Representative traces of the AMPA- and NMDA-gated currents at hippocampal perforant path synapses in CB1R WT animals that received repeated injections with vehicle or Δ9-THC for 7 days. Membrane potential was held at +40 mV, and the AMPA-mediated current was isolated by AP5 (50 µM) and bicuculline (10 µM). The NMDA-mediated current was obtained by subtraction of the AMPA component from the total currents. Scale bar: 50 pA/100 msec. A2. Chronic in vivo exposure to Δ9-THC reduces the ratio of AMPA/NMDA-mediated currents (Veh: 12 recordings/5 animals, THC: 15 recordings/5 animals). *P<0.05 compared with vehicle controls. B1. Representative traces of the AMPA- and NMDA-gated currents at hippocampal perforant path synapses in CB1R KO animals that received repeated injections with vehicle or Δ9-THC for 7 days. B2. Repeated in vivo exposures to Δ9-THC fail to change the ratio of AMPA/NMDA-mediated currents in CB1KO mice (Veh: 13 recordings/5 animals, THC: 12 recordings/5 animals).