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Correlation of C34 inhibitory potency with N36/C34 stability. C34 peptide variants containing substitutions at position Trp-631 were tested for inhibition of viral entry (•) and cell-cell fusion (○). IC50 values (Table 2) are plotted on a logarithmic scale against the Tm of the corresponding N36/C34 complex. The identities and chemical structures of the substitutions are indicated under the corresponding data points. Bars = SD from triplicate experiments.
