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CGRP-stimulated cAMP response of the mutated receptors where there is either an increase in potency or constitutive activity. (a) I32A, (b) G35A, (c) T37A and (d) K51A. Cos-7 cells were transfected with WT/RAMP1 or mutant/RAMP1 and assayed for CGRP-stimulated cAMP production. WT type receptors; open squares. Mutant receptors; as indicated. Data are representative of three to five similar experiments.
