TABLE 1.

EFFECT OF HYPOXIA ON CYTOKINE GENE EXPRESSION USING T CELLS FROM DIFFERENT MOUSE STRAINS

	IL-2		IL-4		IFN-γ		TNF-α
Strain	20% O2	1% O2	20% O2	1% O2	20% O2	1% O2	20% O2	1% O2
Balb/c	1212 ± 110	1328 ± 91	37 ± 5	207 ± 36	262 ± 41	6303 ± 982	ND	ND
C57BL/6	ND	ND	ND	ND	28 ± 7	696 ± 139	ND	ND
C57BL/6x129	1796 ± 134	1161 ± 192	412 ± 62	1155 ± 130	31 ± 5	339 ± 23	209 ± 13	419 ± 36
ICR	413 ± 140	916 ± 31	33 ± 11	215 ± 81	405 ± 26	6612 ± 2221	ND	ND

Definition of abbreviation: ND, not done.

All values are in pg/ml using CD4+ T cells (1 × 10⁶/ml) from female mice stimulated for 72 hours with anti-CD3 plus anti-CD28 antibodies, and are the mean ± SEM of n = 5 (ICR) or n = 6 mice per group.