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Investigational immunosuppressive agents in liver transplantation.
| Immunosuppressive agent | Target pathway |
|---|---|
| FK778 | Interferes with pyrimidine metabolism and DNA synthesis |
| JAK inhibitors | Interfere with Signal 3 transduction |
| FTY720 | Inhibits T cell migration to venule endothelial cells in secondary lymphoid tissue |
| LEA29Y | Interferes with Signal 2 via inhibition of B7/CD28 interaction |
