Table 2.
Urinary excretion of toxic metals in Phase 1, at baseline and after 9th dose of DMSA, in mcg/g creatinine. Creatinine values have units of mg/dL. N = 63. The metals are listed in approximate order of effect of DMSA on excretion. Significant results are highlighted in bold font.
| Element | Baseline | After 9th dose | After 9th dose versus baseline |
|---|---|---|---|
| Pb | 1.3 ± 2.3 | 9.2 ± 7.8 | 638%**** |
| Sn | 2.3 ± 3.4 | 9.7 ± 24 | 314%** |
| Bi | 0.18 ± 0.45 | 0.41 ± 1.0 | 128%** |
| U | 0.015 ± .04 | 0.031 ± .1 | 111% |
| Hg | 0.86 ± .92 | 0.97 ± 0.88 | 13% |
| Tl | 0.15 ± 0.12 | 0.21 ± 0.19 | 42%*** |
| Sb | 0.10 ± 0.10 | 0.14 ± 0.20 | 42%* |
| W | 0.3 ± 0.29 | 0.46 ± 0.50 | 18%** |
| Al | 16 ± 21 | 19 ± 33 | 21% |
| Ni | 6.7 ± 5.1 | 7.6 ± 4.3 | 12% |
| Cd | 0.38 ± 0.24 | 0.3 ± 0.23 | −14% |
| As | 32 ± 20 | 25 ± 18 | −19%** |
| Creatinine | 94 ± 52 | 80 ± 43 | −15%** |
*P < .1, **P < .05, ***P < .01, ****P < .001