Table 10.
Litter size and viability index of the F1 generation rat pups exposed to SE5-OH during gestation and through lactation of the F0 dams.
| Dose (mg/kg/day) | ||||||||
|---|---|---|---|---|---|---|---|---|
| 0 | n | 200 | n | 1000 | n | 2000 | n | |
| Number of total offspring at birth | ||||||||
| Males | #7.6 ± 2.7 | 24 | 7.3 ± 2.5 | 23 | 7.4 ± 2.0 | 22 | 6.7 ± 1.9 | 22 |
| Females | 7.0 ± 2.0 | 24 | 7.3 ± 2.6 | 23 | 6.5 ± 1.7 | 22 | 7.1 ± 2.3 | 22 |
| Total | 14.6 ± 2.8 | 24 | 14.7 ± 1.9 | 23 | 14.2 ± 1.8 | 22 | 13.8 ± 2.3 | 22 |
| (M/F) | (183/168) | (169/169) | (162/144) | (147/157) | ||||
| Number of live offspring at birth | ||||||||
| Males | 7.5 ± 2.8 | 24 | 7.3 ± 2.6 | 23 | 7.2 ± 2.3 | 22 | 6.6 ± 2.0 | 22 |
| Females | 6.9 ± 2.0 | 24 | 7.2 ± 2.4 | 23 | 6.4 ± 2.2 | 22 | 7.1 ± 2.3 | 22 |
| Total | 14.4 ± 3.0 | 24 | 14.4 ± 1.6 | 23 | 13.6 ± 3.3 | 22 | 13.8 ± 2.3 | 22 |
| (M/F) | (179/166) | (167/165) | (159/140) | (146/157) | ||||
| Number of live offspring on PND 4 before culling | ||||||||
| Males | 7.4 ± 2.8 | 24 | 7.2 ± 2.6 | 23 | 7.1 ± 2.4 | 22 | 6.5 ± 1.8 | 22 |
| Females | 6.7 ± 2.0 | 24 | 7.1 ± 2.3 | 23 | 6.2 ± 2.1 | 22 | 7.0 ± 2.3 | 22 |
| Total | 14.1 ± 2.9 | 24 | 14.3 ± 1.6 | 23 | 13.3 ± 3.5 | 22 | 13.5 ± 2.2 | 22 |
| (M/F) | (178/160) | (166/164) | (156/137) | (144/154) | ||||
| Number of live offspring on PND 4 after culling | ||||||||
| Males | 3.9 ± 0.9 | 24 | 4.0 ± 0.2 | 23 | 4.0 ± 0.2 | 21 | 4.0 ± 0.2 | 22 |
| Females | 3.9 ± 0.4 | 24 | 4.0 ± 0.2 | 23 | 4.0 ± 0.2 | 21 | 4.0 ± 0.3 | 22 |
| Total | 7.8 ± 1.2 | 24 | 8.0 ± 0.0 | 23 | 8.0 ± 0.0 | 21 | 8.0 ± 0.2 | 22 |
| Number of live offspring on PND 21 | ||||||||
| Males | 3.9 ± 0.9 | 24 | 4.0 ± 0.2 | 23 | 4.0 ± 0.4 | 21 | 3.9 ± 0.3 | 22 |
| Females | 3.9 ± 0.4 | 24 | 4.0 ± 0.2 | 23 | 4.0 ± 0.2 | 21 | 3.9 ± 0.4 | 22 |
| Total | 7.8 ± 1.2 | 24 | 8.0 ± 0.0 | 23 | 7.9 ± 0.3 | 21 | 7.8 ± 0.5 | 22 |
| Viability indexA (%) | ||||||||
| PND 0 | 96.86 ± 10.27 | 24 | 98.50 ± 4.99 | 23 | 95.78 ± 19.81 | 22 | 99.62 ± 1.77 | 22 |
| PND 4 | 98.23 ± 3.70 | 24 | 99.42 ± 1.92 | 23 | 93.75 ± 21.38 | 22 | 98.58 ± 4.28 | 22 |
| PND 21 | 100.00 ± 0.00 | 24 | 100.00 ± 0.00 | 23 | 98.81 ± 3.76 | 21 | 98.30 ± 5.84 | 22 |
#Mean ± standard deviation; n: number of litters; PND: postnatal day; Aviability index: PND 0: (number of live offspring born alive/number of offspring born), PND 4: (number of offspring alive on PND 4/number of offspring born alive), PND 21: (number of live weanlings/number of live offspring after culling).