Table 4.
Organ weight changes in male and female breeding Sprague-Dawley rats in the F0 and F1 generations of the two-generation rat study.
| Generation | F0 | F1 | ||||||
|---|---|---|---|---|---|---|---|---|
| Dose (mg/kg/day) (n) | 0 (n = 26) | 200 (n = 26) | 1000 (n = 26) | 2000 (n = 26) | 0 (n = 22) | 200 (n = 22) | 1000 (n = 20) | 2000 (n = 26) |
| Male | ||||||||
|
| ||||||||
| Thyroids, absolute organ weight (mg)A | 30.01±5.45C | 31.65 ± 5.94 | 29.94 ± 3.88 | 30.32 ± 3.95 | 30.19 ± 4.48 | 31.89 ± 4.91 | 35.15±5.27** | 32.09 ± 4.18 |
| Thyroids, relative organ weight (mg)B | 5.23 ± 0.68 | 5.33 ± 0.86 | 5.33 ± 0.73 | 5.34 ± 0.78 | 4.55 ± 0.61 | 4.76 ± 0.73 | 5.48±0.90** | 4.94 ± 0.58 |
| Adrenals, absolute organ weight (mg) | 61.81 ± 7.05 | 63.95 ± 10.16 | 59.48 ± 7.40 | 68.90±9.01** | 62.18 ± 7.30 | 63.96 ± 5.83 | 57.61 ± 7.52 | 62.28 ± 9.25 |
| Adrenals, relative organ weight (mg) | 10.88 ± 1.31 | 10.82 ± 1.68 | 10.57 ± 1.28 | 12.10±1.58** | 9.41 ± 1.14 | 9.56 ± 1.07 | 8.95 ± 1.08 | 9.62 ± 1.57 |
| Seminal Vesicles, absolute organ weight (g) | 3.11 ± 0.33 | 2.90 ± 0.37 | 3.12 ± 0.37 | 3.05 ± 0.34 | 3.40 ± 0.29 | 3.26 ± 0.44 | 3.23 ± 0.39 | 3.13 ± 0.37 |
| Seminal vesicles, relative organ weight (g) | 0.55 ± 0.07 | 0.49±0.09* | 0.55 ± 0.08 | 0.54 ± 0.06 | 0.52 ± 0.08 | 0.49 ± 0.01 | 0.51 ± 0.08 | 0.48 ± 0.06 |
|
| ||||||||
| Generation | F0 | F1 | ||||||
| Dose (mg/kg/day) (n) | 0 (n = 26) | 200 (n = 26) | 1000 (n = 26) | 2000 (n = 26) | 0 (n = 18) | 200 (n = 17) | 1000 (n = 18) | 2000 (n = 19) |
|
| ||||||||
| Female | ||||||||
|
| ||||||||
| Liver, absolute organ weight (g) | 13.70 ± 1.30 | 13.99 ± 1.08 | 14.39 ± 1.62 | 14.48 ± 1.11 | 15.01 ± 1.28 | 15.45 ± 1.86 | 16.02 ± 1.46 | 15.71 ± 1.35 |
| Liver, relative organ weight (g) | 3.86 ± 0.32 | 4.05 ± 0.31 | 4.17±0.35** | 4.23±0.29** | 4.12 ± 0.34 | 4.17 ± 0.41 | 4.36 ± 0.33 | 4.42±0.33* |
Significantly different from control: *P < .05, **P < .01; Aabsolute organ weight is the weight of the organ; Brelative organ weight is the weight of the organ relative to the body weight at necropsy (body weight ratio); Cmean ± standard deviation; n: number of male and female rats per dose group.