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Cell proliferation and matrix elaboration on aligned and unaligned scaffolds. (A) Cells proliferated on both types of scaffolds independent of fiber alignment. (B) Immunohistochemical staining for types I and III collagen (day 7, 20×, bar = 100 μm). (C) Nanofiber organization also guided matrix production on the nanofiber scaffolds, with an aligned collagen I matrix found on the aligned scaffolds (day 7, mean angle analysis). Color images available online at www.liebertonline.com/ten.
