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. Author manuscript; available in PMC: 2010 Oct 2.
Published in final edited form as: J Mol Biol. 2009 Aug 6;392(4):1102–1115. doi: 10.1016/j.jmb.2009.07.093

Figure 7.

Figure 7

Paths of the center of mass of carazolol in the RAMD trajectories starting from the putative ligand-free conformation. left: the first set of 60 simulations with four different acceleration magnitudes; right: the second set of 40 simulations with the smallest acceleration used in the first set. The color scale is from yellow (start) to blue (end). The starting conformation of the receptor is shown in cartoon. For clarity, the second extracellular loop of residues 173 to 196 and the solvated lipid bilayer environment are not shown. The distribution of the paths is similar to in Figure 2, but sub-pathway A2 showed significantly higher frequency than sub-pathway A1 (see text for the detail).