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Snapshots showing interactions between carazolol and the ECL2-TM7 hydrophobic bridge in two egress trajectories, in which the putative ligand-free conformation of the β2AR receptor was used. Left: carazolol interrupted the ECL2- TM7 hydrophobic cluster by pushing F193 rotated away; right: carazolol passed underneath F193 and formed face-to-face packing with the phenyl ring of F193. Two movies showing the egress trajectories are available in Supporting Information (Movies 3–4).
