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. 2010 Jan 21;107(6):2449–2454. doi: 10.1073/pnas.0911813107

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Fig. 1. — The structure of PfA-M17. (A) Diagram of the unbound PfA-M17 monomer colored by domain: N-terminal domain (Green), helical region linking the two domains (Yellow) and C-terminal catalytic domain (Red). The partially disordered loop that sits at the entrance to the active site chamber in the hexameric assembly is shown in magenta. The single zinc atom present in the site 2 position (the site 1 position is unoccupied in this structure, ) is shown as a black sphere and is labeled. (B, C) Cartoon diagrams of the biologically functional PfA-M17 hexamer colored by chain: A (Green); B (Blue); C (Red); D (Yellow) E (Orange) F (Brown). The six active sites line an interior cavity. (D) The molecular surface of by chain (as colored in (B, C). The active site zinc and carbonate of chain B are visible (Purple spheres). Chains C & D are occluded in this view. The position of the loop (with the molecular surface omitted) in chain B that sits at the entrance to the catalytic cavity is shown by yellow coil (residues 246-265). This region is disordered in the other chains.

Inline graphic — The structure of PfA-M17. (A) Diagram of the unbound PfA-M17 monomer colored by domain: N-terminal domain (Green), helical region linking the two domains (Yellow) and C-terminal catalytic domain (Red). The partially disordered loop that sits at the entrance to the active site chamber in the hexameric assembly is shown in magenta. The single zinc atom present in the site 2 position (the site 1 position is unoccupied in this structure, ) is shown as a black sphere and is labeled. (B, C) Cartoon diagrams of the biologically functional PfA-M17 hexamer colored by chain: A (Green); B (Blue); C (Red); D (Yellow) E (Orange) F (Brown). The six active sites line an interior cavity. (D) The molecular surface of by chain (as colored in (B, C). The active site zinc and carbonate of chain B are visible (Purple spheres). Chains C & D are occluded in this view. The position of the loop (with the molecular surface omitted) in chain B that sits at the entrance to the catalytic cavity is shown by yellow coil (residues 246-265). This region is disordered in the other chains.