Figure 1. Infection with SeV causes increased morbidity and mortality in MDA5^−/− mice.

WT and MDA5^−/− mice were infected with 200K pfu SeV and assessed for A) loss of body weight over the PI period and B) mucus production (PAS reactivity). C) WT and MDA5^−/− mice were infected with 200K, 400K and 600K pfu SeV and assessed for viability. N = 4–16 mice, error bars refer to SEM, * P≤0.05.