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. 2010 Jan 22;6(1):e1000828. doi: 10.1371/journal.pgen.1000828

Figure 6. Epistasis analysis of BRCA1 and CtIP in cellular tolerance to topoisomerase inhibitors.

Figure 6

Cellular survival of each genotype was assessed by measuring the amount of ATP in cell lysates after 48-h exposure to CPT (A) or VP16 (B). The survival curves for the CtIPS332A/−/−BRCA1−/− cells and their control CtIP+/−/−BRCA1−/− cells are depicted in red. At least five independent experiments were performed with triplicate samples, and the representative results are shown. The error bars indicate S.D.