. Author manuscript; available in PMC: 2011 Feb 1.

Published in final edited form as: Hum Genet. 2009 Nov 10;127(2):207–221. doi: 10.1007/s00439-009-0763-1

Table 4.

DDX58 (RIG-I) haplotype associations with rubella virus-specific TNF-α cytokine secretion

DDX58 haplotype^a	Frequency	Test statistic (haplotype t statistic)	Allele P value^b	Global P value
AAGGCCGGGC	0.065	−0.47	0.636	0.030
AGAGGCGGAC	0.043	−1.18	0.237
AGAAGAAGGG	0.370	−2.56	0.011
TAAGGCACGC	0.213	1.85	0.065
TAAGGCGGAC	0.200	0.08	0.939
TAGGCCGGGC	0.070	2.13	0.034

Haplotype effects are estimated using the haplotype t-statistic, which reflects the direction and relative magnitude of the estimated haplotypic effect on the cytokine measure. Allele P values compare individual haplotypes to all other haplotypes combined. Statistically significant P values (P < 0.05) are highlighted in bold

DDX58 genetic variants from left to right: rs592515, rs6476363, rs669260, rs4633144, rs13300238, rs10813829, rs11795343, rs3824456, rs10813831, rs3739674

One degree-of-freedom ordinal P value from the repeated measures regression analysis adjusting for age at enrollment, gender, race, age at first MMR, time from second MMR to enrollment, and cohort status