TABLE 2.
Odds Ratios (95% Confidence Intervals)a of Quartiles of trans-Fatty Acid Intake with Distal Colorectal Cancer Risk by Race (n=1908), NCCCS II, 2001–2006
| Whites (n=1516) |
African-Americans (n=392) |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| TOTAL TRANS-FATTY ACID CONSUMPTION | |||||||||
| Quartiles of intake | Median grams of trans- fatty acid/day (IQR) | No. of cases | No. of controls | OR | 95% CI | No. of cases | No. of controls | OR | 95% CI |
| Q1 | 4.40 (3.70, 4.84) | 146 | 216 | 1.00 | 53 | 24 | 1.00 | ||
| Q2 | 5.66 (5.41, 5.92) | 154 | 203 | 1.13 | 0.82, 1.56 | 60 | 36 | 1.08 | 0.52, 2.24 |
| Q3 | 6.65 (6.39, 6.91) | 213 | 198 | 1. 54 | 1.12, 2.13 | 54 | 42 | 0.98 | 0.47, 2.05 |
| Q4 | 8.30 (7.73, 9.29) | 204 | 182 | 1.45 | 1.04, 2.03 | 66 | 57 | 0.87 | 0.42, 1.81 |
| p-value for trend test | 0.008 | 0.60 | |||||||
| 16:1 TRANS-HEXADECENOIC ACID CONSUMPTION | |||||||||
| Quartiles of intake | Median grams of trans- fatty acid/day (IQR) | No. of cases | No. of controls | OR | 95% CI | No. of cases | No. of controls | OR | 95% CI |
| Q1 | 0.05 (0.04, 0.06) | 167 | 211 | 1.00 | 67 | 29 | 1.00 | ||
| Q2 | 0.07 (0.07, 0.08) | 162 | 203 | 1.08 | 0.79, 1.47 | 48 | 36 | 0.93 | 0.47, 1.85 |
| Q3 | 0.09 (0.08, 0.10) | 169 | 202 | 1.14 | 0.83, 1.58 | 53 | 38 | 0.88 | 0.44, 1.75 |
| Q4 | 0.13 (0.11, 0.16) | 219 | 183 | 1.57 | 1.14, 2.17 | 65 | 56 | 0.90 | 0.46, 1.78 |
| p-value for trend test | 0.006 | 0.75 | |||||||
| 18:1 TRANS-OCTADECENOIC ACID CONSUMPTION | |||||||||
| Quartiles of intake | Median grams of trans- fatty acid/day (IQR) | No. of cases | No. of controls | OR | 95% CI | No. of cases | No. of controls | OR | 95% CI |
| Q1 | 3.77 (3.20, 4.16) | 153 | 215 | 1.00 | 55 | 25 | 1.00 | ||
| Q2 | 4.99 (4.65, 5.10) | 149 | 204 | 1.01 | 0.73, 1.40 | 57 | 35 | 1.01 | 0.48, 2.09 |
| Q3 | 5.77 (5.55, 6.03) | 210 | 200 | 1.38 | 1.00, 1.90 | 54 | 40 | 0.99 | 0.48, 2.07 |
| Q4 | 7.28 (6.76, 8.21) | 205 | 180 | 1.36 | 0.98, 1.88 | 67 | 59 | 0.81 | 0.39, 1.66 |
| p-value for trend test | 0.02 | 0.52 | |||||||
| 18:2 TRANS-OCTADECADIENOIC ACID CONSUMPTION | |||||||||
| Quartiles of intake | Median grams of trans- fatty acid/day (IQR) | No. of cases | No. of controls | OR | 95% CI | No. of cases | No. of controls | OR | 95% CI |
| Q1 | 0.52 (0.44, 0.56) | 143 | 210 | 1.00 | 64 | 30 | 1.00 | ||
| Q2 | 0.64 (0.62, 0.66) | 150 | 201 | 1.13 | 0.82, 1.57 | 56 | 38 | 1.05 | 0.54, 2.05 |
| Q3 | 0.74 (0.71, 0.77) | 202 | 197 | 1.49 | 1.06, 2.08 | 55 | 43 | 1.02 | 0.50, 2.06 |
| Q4 | 0.89 (0.84, 0.97) | 222 | 191 | 1.53 | 1.09, 2.15 | 58 | 48 | 1.02 | 0.50, 2.10 |
| p-value for trend test | 0.006 | 0.98 | |||||||
OR: odds ratio; 95%CI: 95% Confidence Interval, IQR: Interquartile range
a
Adjusted for energy intake, energy-adjusted total fatty acid consumption, age, sex, BMI 1 year prior, highest level of education attained, and family history of colorectal cancer