Table 4.

 Incidence rate ratios for risk of colorectal cancer by increasing levels of circulating 25-(OH)D and dietary calcium

Tertiles of dietary calcium intake level (mg/day)	Categories of serum 25-(OH)D (nmol/l)
	1 (<50.0)	2(≥50.0 to <75.0)	3(≥75.0)
1 (<797.5)	1.33 (1.14 to 1.54)	1.11 (1.01 to 1.22)	0.85 (0.69 to 1.02)
2 (≥797.5 to <1113.5)	1.17 (1.07 to 1.27)	1.00	0.80 (0.69 to 0.90)
3 (≥1113.5)	0.95 (0.80 to 1.13)	0.85 (0.73 to 0.98)	0.72 (0.57 to 0.91)

Data are incidence rate ratio (95% confidence interval) derived from the multivariate adjusted models described in the text based on a dose-response analysis with predefined categories of circulating 25-(OH)D and tertiles of dietary calcium intake. P value for statistical interaction of circulating 25-(OH)D with dietary calcium=0.154. For this analysis, the total number of colorectal cancer case-control sets is 1220 due to missing nutrient data from Greece.