Table 5.

 Incidence rate ratios for risk of colorectal cancer by increasing levels of circulating 25-(OH)D and alcohol and dietary retinol

	Categories of circulating 25-(OH)D (nmol/l)
	1 (<50.0)	2 (50.0 to <75.0)	3 (≥75.0)
Sex specific categories of dietary alcohol intake level (g/day)
1 (men <1.0, women <1.0)	1.13 (1.03 to 1.26)	1.00	0.82 (0.70 to 0.96)
2 (men 1.0 to <25.0, women 1.0 to <15.0)	1.19 (1.07 to 1.32)	1.04 (1.00 to 1.08)	0.85 (0.75 to 0.98)
3 (men ≥25.0, women ≥15.0)	1.46 (1.16 to 1.83)	1.25 (1.02 to 1.52)	1.01 (0.74 to 1.29)
Tertiles of dietary retinol intake level (μg/day)
1 (<503.5)	1.23 (1.10 to 1.37)	1.00	0.73 (0.62 to 0.86)
2 (503.5 to <998.8)	1.20 (1.08 to 1.33)	1.01 (0.96 to 1.06)	0.78 (0.67 to 0.90)
3 (≥998.8)	1.12 (0.90 to 1.34)	1.04 (0.87 to 1.22)	0.94 (0.71 to 1.22)

Data are incidence rate ratio (95% confidence interval) derived from the multivariate adjusted models described in the text based on a dose-response analysis with pre-defined categories of circulating 25-(OH)D and sex specific categories of alcohol, and tertiles of retinol intake. Alcohol P value for interaction=0.283. Dietary retinol P value for interaction=0.030. For the analyses involving retinol, the total number of colorectal cancer case-control sets is 1220 due to missing nutrient data from Greece.