TABLE 1.
Anthropometrics and metabolic data of study participants
| Control, CC genotype | TCF7L2 genotypes TT and TC | P | |
|---|---|---|---|
| n | 10 | 8 | |
| Demographics | |||
| Age (years) | 44.8 ± 2.5 | 43.3 ± 4.5 | 0.80 |
| Women (%) | 80 | 90 | 0.64 |
| Caucasian/African American (n) | 7/3 | 6/2 | 0.64 |
| Body weight (kg) | 92.3 ± 4.1 | 93.8 ± 5.4 | 0.80 |
| BMI (kg/m2) | 31.9 ± 1.3 | 34.2 ± 2.1 | 0.32 |
| Body fat (%) | 38.9 ± 2.1 | 38.2 ± 3.1 | 0.85 |
| Glucose homeostasis | |||
| Fasting glucose (mmol/l) | 5.3 ± 0.1 | 5.3 ± 0.2 | 0.70 |
| 2-hour glucose (mmol/l) | 7.7 ± 0.3 | 8.6 ± 0.5 | 0.09 |
| Hemoglobin A1C (%) | 5.7 ± 0.5 | 5.7 ± 0.5 | 0.92 |
| Insulin secretion indices | |||
| Static β-cell responsivity Φs (109 min−1) | 67.4 ± 8.8 | 40.7 ± 3.7 | 0.02 |
| Dynamic β-cell responsivity Φd (109) | 1,119 ± 265 | 662 ± 147 | 0.18 |
| Overall β-cell responsivity Φo (109 min−1) | 94.4 ± 15.4 | 46.6 ± 4.2 | 0.01 |
| Insulin sensitivity SI (103 min−1 per pmol/l) | 14.2 ± 2.4 | 15.3 ± 2.5 | 0.41 |
| Insulin clearance (ml/min) | 1,941 ± 163 | 2,157 ± 38,122 | 0.49 |
Data are means ± SE. Statistically significant P values are shown in bold.