TABLE 4.

Loci for which there is evidence for association using repeated A1C values (stages 3 and 4)

Chromosome	SNP	Position	Stage 2: repeated A1C P		Stage 3: repeated daily glucose P			Stage 3: mean glucose by genotype (mg/dl)			Stage 4: repeated A1C P value (COMB = CON +INT)
			CON	INT	CON	INT	COMB	C homo (SE)	Het (SE)	R homo (SE)	SNP P	SNP treatment interaction
9	rs10810632	16,779,024	9.0 × 10−8	0.44	9.7 × 10−3	0.62	0.52	216 (2)*	226 (5)*	259 (25)*	9.2 × 10−3	7.9 × 10−4
9	rs6475082	16,779,436	1.8 × 10−7	0.44	0.011	0.62	0.52	216 (2)*	225 (5)*	259 (25)*	0.011	1.1 × 10−3
9	rs4961760	16,779,878	1.6 × 10−7	0.44	0.012	0.62	0.53	216 (2)*	225 (5)*	259 (25)*	0.010	1.1 × 10−3
9	rs2254193	16,791,850	2.0 × 10−7	0.67	8.3 × 10−3	0.50	0.34	216 (2)*	229 (6)*	253 (27)*	0.011	3.1 × 10−3
10	rs1358030	108,113,589	6.9 × 10−10	0.012	2.7 × 10−5	5.8 × 10−3	1.5 × 10−6	208 (3)*	223 (3)*	228 (5)*	3.8 × 10−10	0.013
14	rs11624318	94,375,765	9.4 × 10−4	2.9 × 10−3	0.40	0.035	0.025	180 (1)‡	182 (2)‡	170 (4)‡	2.7 × 10−7	0.95
14	rs11160219	94,405,244	1.1 × 10−5	0.023	0.37	0.58	0.49	181 (1)‡	180 (2)‡	176 (4)‡	4.3 × 10−7	0.25
14	rs8007115	94,407,241	2.2 × 10−5	0.017	0.38	0.78	0.49	181 (1)‡	180 (2)‡	176 (4)‡	5.4 × 10−7	0.37
15	rs493218	51,277,554	0.77	5.2 × 10−7	0.32	0.10	0.074	149 (1)†	145 (2)†	142 (7)†	8.9 × 10−3	2.4 × 10−4
15	rs572221	51,291,924	0.83	6.6 × 10−7	0.26	0.088	0.056	149 (1)†	145 (2)†	142 (7)†	8.3 × 10−3	3.6 × 10−4
15	rs690271	51,291,964	0.83	5.0 × 10−7	0.26	0.085	0.050	149 (1)†	145 (2)†	142 (7)†	7.6 × 10−3	3.4 × 10−4
15	rs566369	51,295,884	0.82	5.0 × 10−7	0.26	0.085	0.050	149 (1)†	145 (2)†	142 (7)†	7.6 × 10−3	3.4 × 10−4
15	rs482541	51,296,486	0.82	5.0 × 10−7	0.26	0.085	0.050	149 (1)†	145 (2)†	142 (7)†	7.6 × 10−3	3.4 × 10−4

*Data are presented only for SNPs that were close to or met genome-wide significance (P < 5 × 10⁻⁸) from stage 2 using the longitudinal repeated measures in the conventional treatment group and either nominal significance in stage 3 for the intensive group, or reach genome-wide significance when both treatment groups were combined. For the intensive group only analysis, monthly measures were used. For the CON + INT analysis, only quarterly measures were used for the intensive group, so that they would be comparable to the conventional group. C homo, Het, and R homo are least square means of daily mean of the back-transformed Ln(glucose) in the common homozygote, heterozygote, and rare homozygote genotype groups, respectively, in one of the following groups: *CON,

†INT,

‡COMB. NB. The statistical analysis of the glucose measures was performed using normal scores.