Figure 2.

Body weight, food consumption, and adipose tissue mass of Y1-R^+/+ and Y1-R^−/− mice. (A and B) Growth curves of Y1-R^+/+ (males: n = 8; females: n = 7) and Y1-R^−/− (males: n = 10; females: n = 8) mice from 4 to 24 weeks of age (A: males; B: females). Each data point is the mean ± SE, and ∗ indicate values of statistical significance (P < 0.05), as determined by two-tailed unpaired Student’s t tests. (C) The rate of weight gain between 6 and 24 weeks of Y1-R^−/− and Y1-R^+/+ mice. Each data point is the mean ± SE, and ∗ indicate values of statistical significance (∗, P < 0.05, ∗∗, P < 0.01), as determined by two-tailed unpaired Student’s t tests. (D) The food intake of Y1-R^+/+ (males: n = 8; females: n = 7) and Y1-R^−/− (males: n = 10; females: n = 8) mice were monitored over a 20-week period (4–24 weeks). All values are means ± SE. A two-tailed unpaired Student’s t test was used for statistical analysis. (E and F) After measurement of body weight, the fat pads from the indicated sites were weighed (E: males; F: females). ∗, P < 0.05; ∗∗, P < 0.01.