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F2 VALUE CALCULATION AT PH 6.8 PHOSPHATE BUFFER (MEAN CPR)*
| Time(t) | f2 value of optimized formulation (F4) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| n 1 | n 2 | n 3 | n 4 | n 5 | n 6 | n 7 | n 8 | Sum | |
| Reference | 26.9 | 28.8 | 29.2 | 32.1 | 34.5 | 42.7 | 66.5 | 88.4 | - |
| Test | 31.9 | 34.6 | 34.9 | 36.1 | 40.1 | 46.8 | 46.8 | 73.9 | - |
| Rt-Tt | −5.0 | −5.7 | −5.7 | −4.0 | −5.6 | −4.1 | −7.4 | −5.1 | - |
| (Rt-Tt)2 | 25.0 | 32.49 | 32.49 | 16.0 | 31.36 | 16.81 | 54.76 | 26.01 | 234.92 |
f2=50*log{[1+(1/nsum(Rt-Tt)^2]−0.5}*100=62.94066786
CPR= Cumulative percent release, n1-n8= Time points, n= Mean time points
