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F2 VALUE CALCULATION AT PH 7.4 PHOSPHATE BUFFER (MEAN CPR)*
| Time(t) | f2 value of optimized formulation (F4) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| n 1 | n 2 | n 3 | n 4 | n 5 | n 6 | n 7 | n 8 | Sum | |
| Reference | 23 | 33.4 | 43.9 | 47.7 | 68.9 | 82.7 | 86.1 | 96.6 | - |
| Test | 28.1 | 33.9 | 36.4 | 49.6 | 50.6 | 73.7 | 87.6 | 97.0 | - |
| Rt-Tt | −5.1 | −5.1 | 7.5 | −1.9 | 18.3 | 9.0 | −1.5 | −0.4 | - |
| (Rt-Tt)2 | 26.01 | 0.25 | 56.25 | 3.61 | 334.89 | 81.0 | 22.5 | 0.16 | 234.92 |
f2=50*log{[1+(1/nsum(Rt-Tt)^2]-0.5}*100
CPR= Cumulative percent release, n1-n8= Time points, n= Mean time points
