Figure 3. N-WASP EKO mice exhibit an increased number of anagen-phase HFs compared with WT mice at 8 weeks of age, which rapidly declines by 10 weeks.

(A) H&E staining of the WT and N-WASP EKO skin. WT follicles were predominantly in telogen phase. The majority of N-WASP EKO follicles showed typical characteristics of beginning anagen phase, such as proliferation-driven thickening and elongation of keratinocyte strand (arrows) near dermal papilla (arrowheads). Original magnification, ×20. (B) Analysis of HF changes over time in unmanipulated WT and N-WASP EKO mice at 4 weeks (n = 8), 8 weeks (n = 10), and 10 weeks (n = 6) of age. HFs in anagen, telogen, and catagen phases were scored and expressed as a percentage of the total number of follicles counted. Error bars indicate the SD of anagen-phase follicles.