Figure 4. Ang II–induced aortic aneurysms in mice treated with anti–TGF-β antibody are not prevented by inhibition of IFN-γ, IL-4, IL-6, or TNF-α signaling.

Kaplan-Meier curves of survival free from aneurysm rupture and quantification of aortic aneurysm incidence in all groups of mice. (A) Deficiency of T and B cells in Rag2^–/– mice (n = 21) slightly but significantly reduced aneurysm incidence and severity compared with controls (n = 26). (B and C) However, inhibition of IFN-γ (n = 10) or TNF-α (n = 20) signaling or genetic deficiency in IL-4 (n = 10) or IL-6 (n = 10) did not afford protection. Results for the Ang II + anti–TGF-β group are shown only for comparison, but the experiments were not conducted simultaneously with the other groups of mice.