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Quantitative measurement of CBF through the neocortex, forebrain (including the striatum, pallidum, and amygdala), thalamus, corpus callosum, fimbria of the hippocampus, and internal capsula in 18-month-old TgNotch3R169C compared with TgNotch3WT and nontransgenic mice showed diffuse cerebral hypoperfusion in mutant mice. Each of these large areas included 8–10 gray matter regions or 4–5 white matter regions.
