Figure 7. Impaired cerebrovascular autoregulation and attenuated functional hyperemia in young TgNotch3^R169C mice.

(A) Autoregulation curves of CoBF in 5-month-old nontransgenic, TgNotch3^WT, and TgNotch3^R169C mice in response to provoked hypotension showed that CoBF remained above 90% (lower dotted line, considered as the lower limit of autoregulation) up to 60 mmHg in TgNotch3^WT and nontransgenic mice, but only up to 80 mmHg in TgNotch3^R169C mice. (B) CoBF (in percent change) changes in response to arterial blood pressure increase (ΔMABP, in mmHg) induced by phenylephrine infusion (40 μg/kg), in 5-month-old nontransgenic, TgNotch3^WT, and TgNotch3^R169C mice showing a smaller CoBF increase in mutant mice. (C) CoBF increase (%) in the somatosensory cortex in response to whisker stimulation in 5- to 6-month-old nontransgenic, TgNotch3^WT, and TgNotch3^R169C mice showing attenuation of functional hyperemia in mutant mice.