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. 2010 Jan 19;120(2):627–635. doi: 10.1172/JCI39843

Figure 1. Impact of statin therapy on survival of pneumococcal infection in SCD mice.

Figure 1

(A) Survival of WT versus SCD mice receiving mock treatment (n = 26 and n = 24, respectively) or simvastatin (n = 27 and n = 32, respectively) following intranasal challenge with pneumococci; *P = 0.023 versus SCD, **P = 0.0001 versus SCD. (B) Blood and lung bacterial titers at 24 hours after challenge of SCD mice receiving mock or simvastatin treatment. (C) Blood and lung bacterial titers at 24 hours after challenge of WT mice receiving mock or simvastatin treatment. Each symbol represents an individual mouse; horizontal lines indicate the mean; dashed lines indicate limit of detection. *P < 0.01, mock versus simvastatin; Mann-Whitney U test.