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. 2010 Jan 11;120(2):508–520. doi: 10.1172/JCI40045

Figure 5. Stabilized β-catenin antagonizes Kras-induced ADM.

Figure 5

(A–L) Characterization of 6-week-old PBS- and caerulein-treated p48Cre;β-cateninexon3/+;LSL-KrasG12D mice and caerulein-treated p48Cre;LSL-KrasG12D mice. (A, E, and I) H&E staining. Yellow lines separate areas of cells with acinar morphology (a), and ductal morphology (d). (B, F, and J) Amylase staining. (C, G, and K) Sox9 staining. (D, H, and L) Clusterin staining. (M) Quantification of relative amylase area 7 days following caerulein in p48Cre;β-cateninExon3/+;LSL-KrasG12D (red bars) and control p48Cre;LSL-KrasG12D (blue bars) mice. Bars represent mean ± SD. 7 indicates days after caerulein treatment. *P < 0.05; **P < 0.01; ***P < 0.001. Original magnification, ×400 (A–L).