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Pattern of β-catenin signaling activity during acinar regeneration versus Kras-induced ADM/PanIN. β-catenin levels are kept below a critical threshold during the initiation of Kras-induced ductal reprogramming but increase as PanIN lesions form. Therefore, β-catenin antagonizes specification of a ductal state capable of forming PanINs, but likely contributes to PanIN progression and tumor growth.
