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. 2010 Jan 4;120(2):582–592. doi: 10.1172/JCI40568

Figure 4. Osmr–/– mice have reduced bone remodeling and increased adipogenesis.

Figure 4

Bone formation (A–E), marrow adipogenesis (F), and bone resorption (G–I) parameters in 12-week-old male and female Osmr–/– proximal tibiae. OV/BV, OTh, OS/BS, NOb/BPm, and ObS/BS were reduced in 12-week-old female and male Osmr–/– mice compared with WT littermates. Marrow adipocyte volume (AV/MV) was significantly increased in male and female 12-week-old Osmr–/– mice compared with WT mice. NOc/BPm and OcS/BS were significantly reduced in 12-week-old male and female Osmr–/– mice, and CtgV/BV was elevated, confirming a reduction in bone resorption. Data are shown as mean + SEM. *P < 0.05; **P < 0.01 vs. WT littermates. n = 8–10 per group.