Skip to main content
. Author manuscript; available in PMC: 2010 Jan 22.
Published in final edited form as: J Med Chem. 2009 Feb 26;52(4):952–963. doi: 10.1021/jm8008103

Table 4.

Sulfonyls

Sulfonyls Biological Data
Compound Structure KASIII IC50 (μM) P.f. W2 IC50 (μM) P.f. D6 IC50 (μM) P.f. TM91C235 IC50 (μM)
3a graphic file with name nihms164354t19.jpg 0.38 3.2 3.6 ND
3b graphic file with name nihms164354t20.jpg 0.44 20.4 3.9 ND
3c graphic file with name nihms164354t21.jpg 0.13 5.5 0.01 ND
3d graphic file with name nihms164354t22.jpg 157.5 68.9 35.7 111.9
3e graphic file with name nihms164354t23.jpg 63.8 3.6 0.79 5.3
3f graphic file with name nihms164354t24.jpg 192.6 64.3 37.8 60.5
3g graphic file with name nihms164354t25.jpg 22.5 23.5 18.5 32.7
3h graphic file with name nihms164354t26.jpg 114.6 45.7 38.6 80.8
3i graphic file with name nihms164354t27.jpg 27.2 23.6 19.7 3.4
3j graphic file with name nihms164354t28.jpg 22.0 >55.3 0.30 >55.3
3k graphic file with name nihms164354t29.jpg 48.1 20.7 29.2 31.7
3l graphic file with name nihms164354t30.jpg 53.7 >230.2 >230.2 >230.2
3m graphic file with name nihms164354t31.jpg 18.3 1.2 0.43 1.4
3n graphic file with name nihms164354t32.jpg 0.52 5.8 3.0 ND
3o graphic file with name nihms164354t33.jpg 447.7 >50.1 >50.1 ND
3p graphic file with name nihms164354t34.jpg 164.6 >50.1 28.0 ND
3q graphic file with name nihms164354t35.jpg 62.9 84.1 45.3 >203.7
3r graphic file with name nihms164354t36.jpg 0.32 >41.2 >41.2 ND
3s graphic file with name nihms164354t37.jpg 38.2 7.1 26.0 4.5