. Author manuscript; available in PMC: 2010 Jan 22.

Published in final edited form as: J Med Chem. 2009 Feb 26;52(4):952–963. doi: 10.1021/jm8008103

Table 7.

Selected Compounds Were Tested for Toxicity in Vitro against a Subclone (G8) of the Murine Monocyte-like Macrophage line J774

compd^a	mammalian cell in vitro toxicity (IC₅₀, μM)	in vitro therapeutic index^b
1d	123.8	12.4
1h	>1428.0	>204.0
2a	>2544.0	195.6
2b	31.3	<0.62
2c	>1612.0	>268.7
3a	>3184.0	>1061.3
3b	104.8	5.3
3d	134.0	1.9
3e	>1886.0	>471.5
3f	>1893.0	>29.6
3g	7.3	0.30
3h	107.0	2.3
3i	27.6	1.2
3k	>1618.0	>77.0
3l	>1773.0	7.7
3m	>2849.0	>2849.0
3n	0.85	0.15
3o	705.8	<14.0
3p	205.0	<4.1
3q	>1618.0	>19.3
3r	33.6	<0.83
3s	>1184.0	>169.1

See Tables 2–4 for the structures of these compounds.

The in vitro therapeutic index was calculated as the IC₅₀ of macrophage cells divided by the IC₅₀ of the P. falciparum W2 strain.