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. 2009 Sep 22;17(12):2041–2048. doi: 10.1038/mt.2009.218

Figure 2.

Figure 2

In vivo MV-NIS infection of prostate cancer xenografts. Histological sections reveal persistent infection and extensive syncytia formation in LNCaP xenografts 14 days after a single intravenous (IV) administration of 1.5 × 106 TCID50 of measles virus–sodium iodide symporter (MV-NIS). (a) Hematoxylin and eosin (H&E) staining of LNCaP tumor 14 days after IV MV-NIS injection. Extensive syncytia formation within the tumor is shown (arrow) (original magnification ×200). (b) in situ hybridization for MV-NIS N mRNA confirms viral replication in these tumors (original magnification ×200).