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. Author manuscript; available in PMC: 2010 Jan 22.
Published in final edited form as: Int J Dev Biol. 2007;51(2):97–105. doi: 10.1387/ijdb.062237ma

Fig. 1. Localization of migratory and post-migratory NCCs in Ednra−/−;R26R;Wnt1-Cre embryos.

Fig. 1

Lateral (A–F) and ventral (E’,F’) views of Ednra+/+;R26R;Wnt1-Cre (A,C,E,E’) and Ednra−/−;R26R;Wnt1-Cre (B,D,F,F’) embryos. (A,B) At E8.5, β-gal-stained cells (blue) are observed in both Ednra+/+;R26R;Wnt1-Cre (A) and Ednra−/−;R26R;Wnt1-Cre (B) embryos extending from the neural tube toward pharyngeal arch 1 (1) and two (2), with no observed differences present between the two embryos. (C, D) At E9.5, stained cells are observed in Ednra+/+;R26R;Wnt1-Cre (C) and Ednra−/−;R26R;Wnt1-Cre (D) embryos in the frontonasal prominence, maxillary and mandibular portions of the first arch and second, third (3), fourth (4) and sixth (6) arches. No differences are observed in these regions, though stained cells in the outflow tract of wild type embryos appears to extend more distally than those in the outflow of Ednra−/−;R26R;Wnt1-Cre embryos (arrow). (E,F) The staining pattern in E10.5 embryos is similar to that observed at E9.5, with stained cells present throughout the pharyngeal arches (see also ventral views, E’ and F’). However, an apparent delay in NCC migration through the outflow tract in Ednra−/−;R26R;Wnt1-Cre embryos is still apparent (compare arrows in E and F). h, heart.