Table 1.

Summary of Sex Effects in Pharmacogenetic Studies of Nicotine Dependence Trials

Gene	Treatment	Sex Interaction	Reference
CYP2A6	NRT	Not Reported	Malaiyandi et al. (2006)
CYP2A6 (3-HC/COT)	NRT	Not Reported	Lerman et al. (2006b)
CYP2B6	Bupropion	Yes	Lerman et al. (2002)
	Bupropion	No	Lee et al. (2007)
DRD2 (Taq1A)	NRT	Yes	Yudkin et al. (2004)
	NRT	No	Johnstone et al. (2004)
	Bupropion	Yes	Swan et al. (2005)
	Bupropion	No	David et al. (2007a)
	Bupropion	No	David et al. (2007b)
	Venlafaxine	Not Reported	Cinciripini et al. (2004)
	Venlafaxine	Not Reported	Robinson et al. (2007)
DRD2 (−141 Ins/Del)	NRT	No	Lerman et al. (2006a)
	NRT	No	Dahl et al. (2006)
	Bupropion	No	Lerman et al. (2006a)
DRD2 (C957T)	NRT	No	Lerman et al. (2006a)
	Bupropion	No	Lerman et al. (2006a)
DRD4	NRT	Not Reported	David et al. (2008)
DBH	NRT	No	Johnstone et al. (2004)
COMT	NRT	Yes	Colilla et al. (2005)
	NRT	No	Johnstone et al. (2007)
	NRT	No	Munafo et al. (2008)
	Bupropion	Not reported	Berrettini et al. (2007)
SLC6A3	Bupropion	No	Lerman et al. (2003)
	Bupropion	No	Swan et al. (2007)
	NRT/Bupropion	No	O’Gara et al. (2007)
OPRMI	NRT	No	Lerman et al. (2004)
	NRT	Not Reported	Ray et al. (2007)
	NRT	Yes	Munafo et al. (2007)
5-HTTLPR	NRT	No	David et al. (2007c)
	NRT	No	Munafo et al. (2006)
CHRNA4	NRT	No	Hutchison et al. (2007)

Note. NRT = Nicotine Replacement Therapy.