FIG. 2.

Methylene blue-basic fuchsine (A, C, D, E) and hematoxylin and eosin (B) stained or unstained (F) histological sections of (A, B) Mps-BMP^low and (C–F) Mps-BMP^high composites after 9 weeks of subcutaneous implantation in goats. (A) Overview and (B) detailed view of an Mps-BMP^low implant showing ingrowth of well-vascularized fibrous tissue into the pores of the composite (vessels indicated by asterisks) and microfragmentation of PLGA in the intact PPF network (indicated by the central excavation and uneven staining of the microspheres at arrows). (C) Bone formation (indicated by letter b) was seen in the center of the pores of the Mps-BMP^high implants. The bone had a woven (D) or lamellar (E) appearance, with osteocytes inside the matrix and osteoblasts on the surface. (F) Despite the little autofluorescence of the tissue, no fluorochromes could be detected in the newly formed bone. Color images available online at www.liebertonline.com/ten.