Fig. 5.

The predicted recommended dose (median of 40,000 replicate values) and proposed starting dose (five-percentile of 40,000 replicate values) based on PK–PD models that were developed using data from a single phase I study, relative to the true recommended dose. Predicted recommended doses and starting doses are plotted for all compounds (1: □; 2: *; 3:+; 4: Δ; 5: ⁃; 6: ▬; 7: ✕; 8: ○; 9: ◊) and for all regimens (a D × 1; b D × 5; c W × 4; d 120 H; e CI)