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. Author manuscript; available in PMC: 2010 Nov 11.
Published in final edited form as: Eur J Neurosci. 2009 Nov 11;30(10):1931–1940. doi: 10.1111/j.1460-9568.2009.06982.x

Figure 1.

Figure 1

Locomotor sensitization during repeated treatment and in the test day. Distance travelled of Paired group rats (a) was assessed in the square locomotor boxes (Environment A), while locomotor activity of Non-paired group rats (b) was assessed in the round chamber (Environment B) following each daily injection of saline or 15 mg/kg of cocaine. Activity on test day (c) was evaluated in the square locomotor boxes, seven days after repeated administration of saline or cocaine. Rats were injected at one-hour intervals with saline, then 5, 10 and 20 mg/kg of cocaine. Data represent mean ± SEM (N = 8 rats per group) of locomotor activity during 60 min following each injection for Paired or Non-paired groups of rats. # p < 0.001: locomotor activity on day 7 compared to day 1. * p < 0.01: compared to rats repeated injected with saline and tested with the same drug dose.