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. Author manuscript; available in PMC: 2010 Jun 9.
Published in final edited form as: Curr Biol. 2009 Jun 9;19(11):R444–R446. doi: 10.1016/j.cub.2009.04.026

Figure 1. Conditioning lesions and regeneration in the CNS and PNS.

Figure 1

The left side of the figure depicts effects in the PNS and the right side depicts effects in the CNS. (A) After only a single PNS lesion, the rate of regeneration (blue) of severed axons is comparatively low. (B) After a conditioning lesion (1) in the PNS, the regeneration in the distal direction (blue) after a more centrally located test lesion (2) is significantly higher. (C) Regeneration in the CNS is minimal without conditioning as severed axons cannot cross scars. (D) A peripheral conditioning lesion (1) stimulates axonal regeneration within a lesion in the CNS (2).