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. Author manuscript; available in PMC: 2011 Jan 14.
Published in final edited form as: J Med Chem. 2010 Jan 14;53(1):325–334. doi: 10.1021/jm901268n

Table 3.

Sensitivity of cell lines expressing Pgp and βIII tubulin

Cell line IC50 (µM) ± SD IC50 (µM) ± SD
1 10i
SK-OV-3 0.0033 ± 0.0002 0.34 ± 0.01
SK-OV-3-MDR 1–6/6a 0.0035 ± 0.0005 0.45 ± 0.01
Rrc 1.8 1.3
HeLa 0.0029 ± 0.0003 0.23 ± 0.03
WTβIIIb 0.0033 ± 0.0008 0.27 ± 0.02
Rrc 1.1 1.2
a

SK-OV-3-MDR 1–6/6 cells were generated from SK-OV-3 by adenoviral expression of MDR-1.

b

HeLa cells were transfected with the βIII tubulin isotype to generate the WTβIII cells.

c

The Rr values were calculated by dividing the IC50 of the genetically engineered line by the IC50 of the parental cell line.