Table 2.
HbA1c, weight, fasting serum glucose, lipid and blood pressure values in patients receiving exenatide or insulin glargine after 26 weeks of treatment
| Variable | Exenatide | Insulin glargine | Between treatment p value | ||||||
|---|---|---|---|---|---|---|---|---|---|
| HbA1c ≤7.4%, weight gain ≤1 kg | N | N | |||||||
| n (%) | 118 | 63 (53.4) | — | 116 | 23 (19.8) | — | |||
| [95% confidence interval (CI)] | [44.0, 62.6] | [13.0, 28.3] | |||||||
| Odds ratio [95% CI] | 4.71 [2.62, 8.46] | <0.001* | |||||||
| n | Actual measurement | n | Change from baseline | n | Actual measurement | n | Change from baseline | ||
| HbA1c (%) | |||||||||
| Least square (LS) mean (s.e.m.)* | 98 | 7.32(0.09) | 98 | −1.25 (0.09) | 102 | 7.31 (0.09) | 102 | −1.26 (0.09) | 0.924† |
| [95% CI] | [7.14,7.50] | [−1.43, −1.07]¶ | [7.13, 7.49] | [−1.44, −1.08]¶ | |||||
| Weight (kg) | |||||||||
| LS mean (s.e.m.)* | 100 | 97.12(0.31) | 100 | −2.73 (0.31) | 104 | 102.83 (0.31) | 104 | +2.98 (0.31) | <0.001† |
| [95% CI] | [96.5,97.7] | [−3.34, −2.11]¶ | [102.2, 103.4] | [2.37, 3.60]¶ | |||||
| n | Actual measurement, mean (s.d.) | n | Change from baseline, LS mean (s.e.m.) | n | Actual measurement, mean (s.d.) | n | Change from baseline, LS mean (s.e.m.) | ||
| Waist circumference (cm) | 117 | 110.2(14.5) | 117 | −1.90 (0.52)¶ | 114 | 112.6 (12.8) | 114 | 1.86 (0.53)¶ | <0.001‡ |
| Fasting serum glucose (mmol/l) | 105 | 8.51(2.55) | 103 | −2.12 (0.25)¶ | 104 | 6.78 (2.67) | 101 | −3.61 (0.25)¶ | <0.001‡ |
| Triglycerides (mmol/l) | 108 | 1.72(0.92) | 105 | −0.33 (0.08)¶ | 108 | 1.79 (1.03) | 108 | −0.38 (0.08)¶ | 0.650‡ |
| Total cholesterol (mmol/l) | 108 | 4.09(0.95) | 105 | −0.36 (0.07)¶ | 108 | 4.36 (0.97) | 108 | −0.21 (0.07)§ | 0.125‡ |
| LDL (mmol/l) | 104 | 2.15(0.77) | 95 | −0.25 (0.06)¶ | 105 | 2.35 (0.84) | 101 | −0.07 (0.05) | 0.017‡ |
| HDL (mmol/l) | 106 | 1.15(0.27) | 101 | 0.01 (0.01) | 106 | 1.17 (0.28) | 106 | 0.02 (0.01) | 0.471‡ |
| Systolic blood pressure (BP) (mmHg) | 117 | 131.5(15.2) | 117 | −2.9 (1.2)** | 114 | 135.5 (17.2) | 114 | 0.7 (1.2) | 0.034‡ |
| Diastolic BP (mmHg) | 117 | 79.3(8.9) | 117 | −0.5 (0.7) | 114 | 80.8 (8.7) | 114 | 0.9 (0.7) | 0.158‡ |
The n values show the number of patients with evaluable data for each variable examined.
*
From logistic regression analysis.
†
From mixed model repeated measurement analysis.
‡
From analysis of covariance.
¶
p < 0.001 for within-group change from baseline.
§
p = 0.004 for within-group change from baseline.
**
p = 0.015 for within-group change from baseline.