Table 2.
Summary of Hypothalamic-Pituitary-Adrenal Axis Phenotype of HSD1−/− Mice, From Different Strain Backgrounds.
| Measure | 129 | 129/MF1 | C57Bl/6J |
|---|---|---|---|
| Adrenal size | ↑ | ↑ | ↑ |
| Basal AM Cort | ↑ | ↑ | ↔ |
| Basal PM Cort | ND | ↔ | ↔ |
| Peak Stress Cort | ND | ↑ | ↑ |
| Recovery Cort | ND | ↑ | ↔ |
| Basal AM ACTH | ND | ↑ | ↔ |
| Basal PM ACTH | ND | ↔ | ↔ |
| Peak Stress ACTH | ND | ↔ | ↔ |
| Recovery ACTH | ND | ↑ | ↔ |
| CRF mRNA (paraventricular nucleus) | ND | ↓* | ↑* |
| GR mRNA (paraventricular nucleus) | ND | ↓ | ↑ |
| GR mRNA (hippocampus) | ↓ | ↔ | ↑ |
| MR mRNA (hippocampus) | ND | ↔ | ↑* |
Arrows designate direction of change in HSD1−/− mice relative to HSD1+/+ mice from the same background: ↑, higher; ↓, lower; ↔, not different. All changes are significant to P < 0.05, except those designated by an asterisk (*), which tend towards change with P < 0.1. Measurements not carried out on a particular background are indicated by ND (not done). ACTH, adrenocorticotrophic hormone; CRF, corticotrophin-releasing factor; AM Cort, morning corticosterone; PM Cort, afternoon corticosterone; GR, glucocorticoid receptor; MR, mineralocorticoid receptor.