TABLE 1.
Effect of GCP II inhibition on intrinsic membrane properties
| Properties | Control | 2-MPPA | P |
|---|---|---|---|
| Vm, mV | −64.2 ± 1.9 | −64.7 ± 1.7 | 0.59 |
| Rm, MΩ | 223.8 ± 7.1 | 230.5 ± 8.7 | 0.64 |
| τm, ms | 45.8 ± 7.1 | 49.9 ± 8.7 | 0.25 |
| AP threshold, mV | −42.4 ± 3.1 | −41.2 ± 3.0 | 0.24 |
| Rheobase, pA | 98.9 ± 1.8 | 98.1 ± 2.0 | 0.15 |
| AP amplitude, mV | 105.7 ± 5.3 | 106.9 ± 5.6 | 0.65 |
| ADP, mV | 3.3 ± 0.9 | 3.4 ± 1.0 | 0.82 |
| fAHP, mV | 4.5 ± 0.5 | 4.9 ± 0.6 | 0.52 |
Recordings from CA3 pyramidal cells (n = 7) before (control) and after application of the glutamate carboxypeptidase II (GCP II) inhibitor, 2-(3-mercaptopropyl)-pentanedioic acid (2-MPPA). Values are expressed as means ± SE. Vm, resting membrane potential; Rm, input resistance; τm, membrane time constant; AP, action potential; ADP, afterdepolarization; fAHP, fast afterhyperpolarizing potential. Statistical comparisons performed by unpaired Student’s t-test, P as indicated.