Table 1. Tumor seeding activity of various carcinoma and melanoma cell lines.
The table indicates the type of cancer, the relationship, species, and name of the cell lines used as donor and recipient pairs, the tumor site (MFP: mammary fat pad, SubQ: subcutaneous), and the fraction of tumors that showed seeding as determined by BLI. MDA231-LM2, a lung metastatic derivative of MDA231; MCF7-BoM2, a bone-metastatic derivative of MCF7; CN34-BrM2, a brain-metastatic derivative of pleural effusion CN34; SW620-LM1, a lung-metastatic derivative of SW620; A375-BoM2, a bone metastatic derivative of A375. PyMT: cells derived from a mammary tumor developed in MMTV-PyMT transgenic mice.
| Cancer | Relationship | Species | Donor tumor | Recipient tumor | Site | Seeding (%) |
|---|---|---|---|---|---|---|
| Breast | Homotypic | Human | MDA231-LM2 | MDA231-LM2 | MFP | 11/13 (85) |
| Breast | Homotypic | Human | MDA231-LM2 | MDA231 | MFP | 39/47 (83) |
| Breast | Homotypic | Mouse | 4T1 | 4T1 | MFP | 3/5 (60) |
| Breast | Homotypic | Mouse | 4T1 | 67NR | MFP | 11/11 (100) |
| Breast | Homotypic | Mouse | PyMT | PyMT endogenous | Breast | 8/11 (73) |
| Breast | Heterotypic | Human | CN34-BrM2 | MDA231 | MFP | 10/19 (53) |
| Breast | Heterotypic | Human | MCF7-BoM2 | MDA231 | MFP | 6/7 (86) |
| Breast | Heterotypic | Human | MDA231-LM2 | MCF7 | MFP | 7/7 (100) |
| Melanoma | Homotypic | Human | A375-BoM2 | A375 | SubQ | 8/11 (73) |
| Colon | Homotypic | Human | SW620-LM1 | SW620 | SubQ | 7/9 (77) |