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. Author manuscript; available in PMC: 2010 Dec 7.
Published in final edited form as: Circ Res. 2009 Oct 22;105(12):1248–1255. doi: 10.1161/CIRCRESAHA.109.208926

Figure 1. gp91ds-tat attenuates chronotropic action of Ang II in SHR and WKY rat neurons.

Figure 1

A and B: Recordings of APs from SHR neurons under the following sequential treatments: Perfusion of PBS, followed by superfusion of Ang II (100 nmol/L); Washout of Ang II; Superfusion of gp91ds-tat (gp91ds, 5 μmol/L) or scrambled gp91ds-tat (Scra, 5 μmol/L); Superfusion of Ang II (100 nmol/L) plus gp91ds-tat (Ang II + gp91ds) or scrambled gp91ds-tat (Ang II + Scra).

C: Bar graph summarizing the effects of gp91ds-tat on the chronotropic action of Ang II in SHR and WKY rat neurons. Data are mean ± SE (n=11). *P<0.01 compared with respective control recordings. #P<0.05 compared recordings between SHR and WKY rat neurons under the same condition. D: Bar graph summarizing the effects of scrambled gp91ds-tat (5 μmol/L) on the chronotropic action of Ang II in SHR and WKY rat neurons. Data are mean ± SE (n=7). *P<0.01 compared with respective control recordings. #P<0.05 compared recordings between SHR and WKY rat neurons under the same condition.